I’ve gone through almost all files within Nexus to test if it’s good or will it satisfy my curiosity or need, before I used a load manager which auto-sorts everything for me which on most occasions due to the enormous amount of mods it seems to crash my game even with the auto-sort and updating unless I use my exported working load order.
But all-in-all it all comes down to whether your game will experience a CTD (crash-to-desktop) or not.
Most people use load order managers to handle positioning of the mods they’ve downloaded whether it be automatically sorted for them or manually done.